Yes.
Only two species of lizards from the family Helodermatidae, found in the arid grasslands and semi-deserts of Arizona and Mexico, are considered poisonous. One of these species is the Gila monster, which is a fairly large reptile measuring up to 60 cm in length, characterized by a bright orange-yellow or reddish-brown pattern. The second species is the Mexican beaded lizard, which is even larger: some individuals can reach nearly a meter in length.
Both species of Helodermatidae hide during the day in burrows and under rocks, preferring a nocturnal lifestyle. With the onset of darkness, they leave their shelters and begin hunting for slow-moving arthropods, newborn rodents, chicks, and bird eggs.
During dry periods, these lizards take refuge in burrows, feeding on fat reserves accumulated in their tails. The bites of these reptiles are very painful and act similarly to snake bites. For small animals, the venom of the Gila monster and the Mexican beaded lizard can be fatal, while in humans it usually causes severe swelling but can rarely lead to death.
