Hidden Harbinger of Alzheimer's Disease Identified 0 10

A sharp increase in blood sugar levels after meals may be associated with a higher risk of developing Alzheimer's disease. This conclusion was reached by researchers from the University of Liverpool, who analyzed large genetic data as part of the UK Biobank project. The results of the study were published in the journal Diabetes, Obesity and Metabolism (DOM).

The scientists studied data from more than 350,000 individuals aged 40 to 69, focusing on carbohydrate metabolism indicators — fasting glucose levels, insulin, and blood sugar two hours after eating. Using Mendelian randomization, the researchers assessed whether these parameters could be causally linked to the risk of dementia.

The analysis showed that individuals with pronounced postprandial hyperglycemia — an increase in sugar specifically after meals — had a 69 percent higher risk of Alzheimer's disease. Moreover, this association was not explained by a reduction in brain volume or damage to white matter, indicating more subtle, yet not fully understood mechanisms of influence.

The authors emphasize that the results require further clinical validation; however, they already highlight the importance of monitoring blood sugar not only on average but also after meals.