Vitamin Named as a Helper in Preserving Muscle Mass in Old Age 0 18

Vitamin K, which is traditionally associated with the blood clotting process, may also play a role in maintaining muscle strength and function in older age. This is stated in a review article dedicated to the connection between vitamin K and sarcopenia — the age-related loss of muscle mass, strength, and endurance, which increases the risk of falls and loss of independence. The work is published in Frontiers in Nutrition.

The authors describe several possible mechanisms. Vitamin K is involved in the activation of so-called vitamin K-dependent proteins — osteocalcin, MGP, and Gas6, which are related to tissue regeneration, vascular health, and energy metabolism in muscles. Additionally, in experimental models, the vitamin has demonstrated anti-inflammatory and antioxidant properties, effects on mitochondrial function, and cellular damage processes, which are considered some of the key factors in age-related muscle tissue loss.

Observational studies more frequently report positive associations: individuals with higher levels of vitamin K show better physical function, grip strength, and a lower risk of functional limitations. However, the results of clinical trials with vitamin supplements remain ambiguous and depend on the form (K1 or K2), dosage, and characteristics of the participants.

The authors emphasize that vitamin K cannot yet be considered a proven means of preventing sarcopenia — larger and more standardized studies are needed. However, maintaining adequate levels of vitamin K in the diet, especially through green leafy vegetables and fermented products, may be viewed as a potentially beneficial factor in a healthy aging strategy.