Tobacco and Cannabis Use Reduces Brain Volume 0 13

Regular use of tobacco and cannabis may be associated with a reduction in the volume of certain areas of the brain. This conclusion was reached by scientists whose meta-analysis results were published in the journal Addiction.

Researchers analyzed data from more than 100 scientific studies involving over 72,000 people. It turned out that individuals who regularly use cannabis more often experience a reduction in the amygdala—a brain area associated with emotions and stress response. In tobacco smokers, changes affected several areas, including the amygdala, insular cortex, and globus pallidus, which are involved in regulating emotions, self-awareness, and movement.

Moreover, smokers experienced a faster decline in overall gray matter volume—an important indicator of brain health related to cognitive functions and mental state. Genetic analysis also showed that more intense smoking is associated with a reduction in the hippocampus—a structure that plays a key role in memory and learning.

The authors emphasize that the study reveals a correlation but does not prove a direct cause-and-effect relationship. Nevertheless, the obtained data allow for a more accurate assessment of which specific areas of the brain may be vulnerable when using these substances and can be used for a clearer explanation of the risks, especially among young people.