In the activity of the central nervous system.
Although these two states have much in common, during anesthesia the phase of “rapid” sleep is often significantly shortened or completely absent, and the overall activity of the central nervous system is significantly lower.
During anesthesia, a person does not feel pain, does not perceive sounds, and does not feel touch; they are virtually impossible to awaken until the effects of the drug wear off.
In some cases, during deep anesthesia, spontaneous breathing may even cease.